Three predicted upregulated miRNAs (miR-223a-3p, miR-23a-3p, and miR-15a-5p) and two downregulated miRNAs (miR-1285-3p and miR-450a-1-3p) were involved in the regulation of mucus production in CRS NLF-EVs by targeting GALNTL2 and B4GALT, which may influence the transference of sialic acids to O-glycan. Here, B4GALNT2 is linked to congenital rubella syndrome.