Of these, mucin-type O-glycan biosynthesis (p = 7.31 × 10−5), Hippo signaling pathway (p = 1.09 × 10−4), FoxO signaling pathway ( p = 3.62 × 10−4), PI3K-Akt signaling pathway (p = 3.75 × 10−3), focal adhesion (p = 6.13 × 10−3), adherens junction (p = 1.49 × 10−2), Rap1 signaling pathway (p = 1.53 × 10−2), and transforming growth factor-beta (TGF-β) signaling pathway (p = 2.21 × 10−2) were the most prominent pathways rich in quantile with differential EV miRNA patterns, suggesting that these biological pathways are involved in CRS development (Figure 3B,C). This evidence concerns the gene MUC5AC and congenital rubella syndrome.