Interestingly, in a prospective randomized trial undertaken to compare crystalloid and colloid fluid resuscitation for patients receiving bolus IL-2-based therapy for metastatic cancer, 5% HAS alleviated hypoalbuminemia despite vascular leak and the incidence of oliguria was markedly reduced by albumin infusion (2.8% vs. 32.5% with normal saline) [28]. The gene discussed is IL2; the disease is Hypoalbuminemia.