Interestingly, in coronary bypass surgery, incidence of acute kidney injury is elevated and plasma levels of HBP are known to increase, [52,53] preoperative serum albumin levels are inversely related to postoperative risk of acute kidney injury development, [54] and in an RCT, preoperative correction of hypoalbuminemia with administration of HAS significantly reduced the occurrence of acute kidney injury [55]. This evidence concerns the gene ALB and acute kidney injury.