As regards the diagnosis of oligodendroglioma, a potential application of SRSF1 would be in the distinction between oligodendrogliomas with astrocytic-like morphology and grade II and III adult astrocytomas, which may present a oligodendroglioma-like cellular component, as SRSF1 appears to be more diffusely expressed in the former and less expressed in the latter; interestingly, SRSF1 seems to be more constantly expressed in grade III anaplastic oligodendrogliomas than their grade II counterparts, as IRS values ≥ 6 were found in all grade III cases (6/6) included in our series. The gene discussed is SRSF1; the disease is oligodendroglioma.