Based on our results, SRSF1 does not appear to be a reliable marker in distinguishing SEGA and PXA from their morphological mimickers; however, given both the glioneuronal phenotype and the presence of BRAFV600E mutations of PXA and the characteristic clinico-pathological features of SEGA, the diagnosis of these entities is usually more straightforward for the neuropathologists. Here, SRSF1 is linked to pleomorphic xanthoastrocytoma.