SRSF1 has been recently characterized as being functionally involved in gliomagenesis: in particular, this protein which normally shuttles between the nucleus (where, once phosphorilated, accumulates in the speakles, contributing to the assembly of the spliceosome) and the cytoplasm (where it interacts with other proteins) is upregulated in GBM and contributes to the aberrant splicing of a plethora of target pre-mRNAs [18,19]. Here, SRSF1 is linked to glioblastoma.