Finally, our study strongly emphasizes the role of SRSF1 as a diagnostic immunomarker of adult diffuse astrocytomas and oligodendrogliomas; in particular, the detection of increased immunohistochemical expression of this protein might be a promising and useful marker in excluding entities that frequently enter in the differential diagnosis of adult gliomas, such as ependymomas and pilocytic astrocytoma; thus, we encourage the diagnostic use of SRSF1 in some specific clinico-pathological settings in neuropathological practice. The gene discussed is SRSF1; the disease is central nervous system cancer.