The molecular characterization of circSMARCA5 has recently been published, a circular RNA has been found to be downregulated in WHO grade IV glioblastoma (GBM) biopsies with respect to normal brain parenchyma; it acts as a decoy for the oncogenic serine and arginine rich splicing factor 1 (SRSF1) [18,19]. This evidence concerns the gene SRSF1 and glioblastoma.