The VEGF-A pre-mRNA splicing mechanism may alternatively generate both pro-angiogenic and anti-angiogenic isoforms [19]; it has been hypothesized that the downregulation of circSMARCA5, through the concomitant upregulation of SRSF1, leads to a switch in the proangiogenic–antiangiogenic ratio of VEGFA, resulting in angiogenic stimulation on GBM tissue [18,19]. This evidence concerns the gene VEGFA and glioblastoma.