The results obtained suggest a relevant diagnostic utility of the SRSF1 protein in distinguishing adult diffuse astrocytomas from ependymomas and PAs, the diagnosis of which may be particularly challenging when tumors arise in adults and in anatomic sites different from the cerebellum; we decided to include PA in the cohort of gliomas studied because, although it is not properly a diffuse adult glioma but a pediatric one, it is an entity that can arise and be diagnosed at any age, and therefore, must be frequently included in the differential diagnosis of low-grade adult gliomas. Here, SRSF1 is linked to ependymoma.