LDLR and coronary artery disorder: Gain of function (GOF) mutations reduce LDLR levels in the liver, resulting in increased LDL-C circulating levels, leading to a high risk of developing CAD; whereas loss of function (LOF) mutations increase LDLR levels, lowering LDL-C circulation levels and, therefore, it has a protective effect against CAD [39,40,41,42,43,44].