As indicated in mice carrying a megakaryocyte/platelet-specific targeted deletion of the TGFβ gene, platelets appear to influence the development of liver fibrosis: they appear to be the primary source of TGFβ stimulating the synthesis of collagen in hepatic stellate cells and favouring their transdifferentiation into myofibroblasts. The gene discussed is TGFB1; the disease is Hepatic fibrosis.