SERPINE1 and malaria: Therefore, in malaria patients, blood platelets may more readily adhere to endothelial cells [93], which also demonstrate a procoagulant phenotype characterised by increased endothelial production of reactive oxygen species, enhanced expression of P-selectin, tissue factor and plasminogen activator inhibitor 1 (PAI-1), and decreased expression of thrombomodulin [94,95].