BRCA1 and breast carcinoma: The most important risk factors for breast cancer appear to be older age, the carrier of mutations in some genes (primarily BRCA1 and BRCA2), the occurrence of breast cancer in relatives, early age of first menstruation, late menopause, late age of first delivery, long-term hormone replacement therapy (HRT), exposure to ionizing radiation, some mild breast proliferative diseases, a low level of physical activity, improper diet, obesity, alcohol, smoking, and night shift work [25,26].