Over the past 15 years, increasing evidence suggests a relevant role of SEC61, SEC62, and SEC63 genes in the development and tumor cell biology of human malignancies (Figure 9) [310,311,312,313,314,315,316,317,318,319,320,321,322,323,324,325,326,327,328,329,330,331,332,333,334,335,336,337,338,339,340,341]. Here, SEC61A1 is linked to neoplasm.