Notably, the MUC1, REN and UMOD genes, which code for the precursors of mucin-1 (MIM: 174000), renin (MIM: 613092) and uromodulin (MIM: 191845), respectively were previously linked to ADTKD [262]. Here, REN is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.