TEK and neoplasm: Noting that TIE2+ tumor-associated macrophages (MΦ) and endothelial progenitor cells have been reported to infiltrate tumors after treatment with CA4P, thereby promoting tumor angiogenesis, [262], it was reasoned that the immune modulator IMQ could potentially convert immature plasmacytoid dendritic cells (pDCs) into their active form, leading to the robust infiltration and priming of natural killer cells and cytotoxic T-lymphocytes in treated tumors.