On the contrary to the aforementioned study demonstrating that Abca7 deficiency does not impact Aβ peptide synthesis [86], other studies reported that the absence of Abca7 in AD transgenic mouse models (APP/PS1 and TgCRND8) promotes the Aβ peptide production [22,83] or that ABCA7 upregulation in vitro diminishes this synthesis [82]. This evidence concerns the gene ABCA7 and Alzheimer disease.