ABCA7 and early-onset autosomal dominant Alzheimer disease: When Hollingworth et al. published that single nucleotide polymorphisms (SNPs) in ABCA7 sequences were strongly associated with Alzheimer’s disease (AD) onset and development [12], a new field of investigation has emerged with the objectives to identify the exact function of ABCA7 in the brain as well as in the apparition and evolution of AD.