Moreover, the presence of CMML-associated genotypes (e.g., TET2/SRSF2) can be useful for the differential diagnosis between CMML and other myeloid-related neoplasms which can also present with monocytosis such as CML, MPN or M4 or M5 AML [4]. Here, SRSF2 is linked to chronic myelomonocytic leukemia.