Several studies have attempted to identify factors that could predict the aggressive behavior of SPNs, including age [6], sex [7], neutrophil-to-lymphocyte ratio [8], tumor size [5,9,10,11], resection margin [6], Ki-67 index [1,12,13,14], pathological variables, such as lymphovascular and perineural invasion [1,12,15], and radiologic findings on magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) [16,17,18,19,20,21]. The gene discussed is MKI67; the disease is neoplasm.