Since the clinical relevance of circulating immune checkpoints as predictors of clinical outcome has yet to be defined in GIST patients, we carried out a Kaplan–Meier survival analysis in order to understand the potential prognostic value of plasma PD-1, PD-L1, BTN3A1, and pan-BTN3As in advanced GIST patients, suggesting that their plasma concentrations could be helpful, in the future, for predicting patient survival (Figure 4). The gene discussed is CD274; the disease is gastrointestinal stromal tumor.