Immune surveillance is often overridden by cancer cells due to the activation of immunomodulatory molecules such as programmed death protein (PD-1) and its ligand PD-L1, Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), and butyrophilin sub-family 3A/CD277 receptors (BTN3A) [16,17,18,19]. This evidence concerns the gene CD274 and cancer.