THOP1 and early-onset autosomal dominant Alzheimer disease: Some relevant pathways include Telomerase Signaling (p = 5.45 × 10−5), FXR/RXR activation (p = 8.86 × 10−5), Type I Diabetes Mellitus (p = 6.08 × 10−5), as well as several neurological pathways, such as Hypoxia-inducible factor 1α (HIF1α) signaling (p = 2.82 × 10−3), Agrin Interactions at Neuromuscular Junction (p = 1.39 × 10−3), Neuregulin Signaling (p = 2.04 × 10−3), and Neuroprotective Role of THOP1 in Alzheimer’s Disease (p = 3.02 × 10−3).