Among the over 50 genes that have been linked to ALS, pathogenic mutations in Superoxide Dismutase-1 (SOD1), Trans-Active Response DNA-Binding Protein 43 (TDP-43), Fused in Sarcoma RNA Binding Protein (FUS), Alsin (ALS2), Senataxin (SETX), Spastic Paraplegia 11 Protein (SPG11), Vesicle-Associated membrane protein-associated Protein B (VAPB), Angiogenin (ANG), and Chromosome 9 Open Reading Frame 72 (C9ORF72) genes are the most frequently found [31,32,33,34,35]. Here, SPG11 is linked to amyotrophic lateral sclerosis.