Recently, in an attempt to identify mitochondria activity differences between stable coronary artery disease (SCAD) and acute coronary syndrome (ACS), the mtDNA copy number and methylation levels of the nuclear peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) and of the D-loop region were evaluated in peripheral blood leukocytes of 50 patients with SCAD and of an equal number of individuals with ACS [86]. Here, PPARGC1A is linked to acute coronary syndrome.