RFC4 and breast cancer: Finally, the increase in expression of the genes CCNE1, FANCI, RFC4, CDC6, and YWHAZ associated with poor prognosis in luminal A breast cancer (OS, HR:2.54, CI 1.69–3.82, log rank p = 3.6 × 10−6; RFS, HR:1.84, CI 1.53–2.22, log rank p = 6.5 × 10−11) (Figure 6D).