Next, we decided to reduce the list of the identified genes by selecting only the 5 common genes, NBN, PRKDC, RFWD2, UBE2T, and YWHAZ, that met our initial criteria for clinical relevance (amplified in more than 5% of cases and with a transcriptomic FC expression of more than 1.5 in all breast cancer subtypes) (Supplementary Figure S3A). The gene discussed is COP1; the disease is breast cancer.