These results align with previous studies that the individual LUT decreases ERα protein by inhibiting ERα gene expression in ERα+ breast cancer cells [19], I3C triggers aryl-hydrocarbon receptor (AhR)-dependent ERα protein degradation [20], and the combined LUT and I3C synergistically reduced ERα mRNA level in MCF7 cells [21]. The gene discussed is ESR1; the disease is breast carcinoma.