NFE2L2 and neoplasm: Under normal physiological conditions, the protective role of NRF2 acting as a tumor suppressor via maintaining cellular redox homeostasis (eliminating ROS and carcinogens) and regulating cell growth is acknowledged, whereas, in many established cancers, upregulation of NRF2 was detected, thereby assisting cancer cells to withstand excessive oxidative stress and diminishing the effects of chemotherapeutic agents and radiotherapy [5,7,11].