NR4A2 and Parkinson disease: However, most of these mRNAs are similarly dysregulated in other neurodegenerative diseases or have not been tested for ALS specificity, with exceptions for FasL mRNA, which showed a significant increase in the peripheral blood leukocytes (PBL) of ALS patients relative to PD, ataxia, and healthy controls [114], and Nurr1, which was downregulated in the peripheral blood of PD patients [114] and upregulated in ALS [113].