Consistent with these observations, previous studies have also reported a decrease in Th1 and increase in Th2 cytokine levels [117,118] such as IL-4, IL-6, IL-8, IL-10, GM-CSF, VEGF, prostaglandin E2 (PGE2), and bFGF during the development and progression of HNSCC [119,120,121]. This evidence concerns the gene CXCL8 and head and neck squamous cell carcinoma.