While the increased IL-10, IL-17A, and IL-22 levels, and decreased IFN-γ expressions are collaborated with the loco-regional metastasis [122,123], increased VEGF, FGF, and IL-8 expression contribute to tumorigenesis, metastasis, and HNSCC angiogenesis [16,124,125]. The gene discussed is IFNG; the disease is head and neck squamous cell carcinoma.