While the interaction of integrins, particularly α5β1 integrin with fibronectin, and αvβ5 with vitronectin were shown to modulate HNSCC cell behavior, αvβ3-osteopontin, αvβ3-fibronectin, and α5β1-fibronectin interactions are involved in angiogenesis [115]. This evidence concerns the gene VTN and head and neck squamous cell carcinoma.