However, patients with CLL exhibited heightened percentage of both LAG-3+ CD4+ T cells (16.3 ± 1.3 vs. 7.5 ± 1.1, p = 0.0001) and CD8+ T cells (28.2 ± 2.0 vs. 11.9 ± 1.5, p < 0.0001) (Figure 4E). This evidence concerns the gene CD4 and B-cell chronic lymphocytic leukemia.