While no significant differences in the percentage of LAG-3 expressing B cells were observed, the level of LAG3 surface expression was found to be significantly upregulated on leukemic cells from patients with CLL (mean fluorescence intensity (MFI) ± standard error of mean (SEM): 426.4 ± 83.5 vs. 142.7 ± 10.1, p = 0.0012) (Figure 1B,C). Here, LAG3 is linked to B-cell chronic lymphocytic leukemia.