As expected, demyelination in the CF model increased from 50% at about 3 weeks to close to 100% at 5 weeks post CF treatment in the CC, despite no significant difference in 18F-PBR111 uptake between the 3.5 and 5.0 week PET imaging time points, which was further confirmed by AR and IF with CD11b and F4/80 staining. Here, ITGAM is linked to cystic fibrosis.