Interestingly, unlike what was observed for human BC cell lines MDA-MB-231 and RT-R-MDA-MB-231, in vivo data showed higher expression levels of vimentin in RT-R-4T1-VE than 4T1-EV group, which were reduced in the 4T1-A2AR-shRNA and RT-R-4T1-A2AR-shRNA groups. Here, ADORA2A is linked to breast cancer.