Activating Kv7.2/3 potassium channels (also known as the M current) by retigabine, an activator of Kv7.2/3 potassium channels drives K+ efflux, counterbalancing the Na+ influx and thus dampening MN hyper-excitability as observed in ALS patient-derived MNs [64] and LVPNs of mouse models [65]. Here, KCNA3 is linked to amyotrophic lateral sclerosis.