Promoter region of the coding gene for CDCP1 is highly rich of CpG island, whose methylation status drives the expression pattern of CDCP1 itself in cancer; this can justify the detection, until 2006, of this transcript product only in K562, considered as the only CDCP1- hematopoietic positive cell lines, which derived from the blast crisis of chronic myeloid leukemia (CML) [34]. The gene discussed is CDCP1; the disease is cancer.