Indeed, the large majority of NUP98 rearrangements in the analysis reported by Bisio et al. [20] are NUP98-NSD1 (11 out of 19); in the TARGET pediatric AML study [9] as well, the only NUP98r observed in PIF patients is NUP98-NSD1. The gene discussed is NSD1; the disease is acute myeloid leukemia.