ARHGEF10 and microcephaly: In accordance with this presumptive role, DECIPHER patient 368323, carrying an SNV (single nucleotide variant) of uncertain clinical significance in ARHGEF10, mainly showed global developmental delay, postnatal microcephaly, encephalopathy and seizure, that are typical features of 8p23.2-pter patients (Table 1 and Table 3).