CASK and microcephaly: Moreover, DLGAP2 interacts with NRXN1, a pre-synaptic cell-adhesion molecule (Figure 2A) and CASK, another scaffolding protein (Figure 2C) and mutations in both NRXN1 and CASK are associated to neurodevelopmental and neurocognitive disabilities and microcephaly [47,48,49].