The CR comprises several genes out of which the OMIM genes FBXO25, DLGAP2, CLN8, ARHGEF10 and MYOM2, most of which share a role in neural differentiation and function [12,13,14,15,16,17], are main candidates for DD/ID, microcephaly and neurobehavioral disorders. Here, ARHGEF10 is linked to microcephaly.