CLN8 and neuronal ceroid lipofuscinosis: Homozygous genetic alterations of CLN8 are associated with neuronal ceroid lipofuscinosis (NCL) (OMIM #600143), a genetically heterogeneous group of neurodegenerative disorders mainly characterized by seizures and progressive neurological deterioration, which result in dementia, ataxia, visual failure, and various forms of abnormal movement.