When tested as individual gene, 9 genes from the 11-ARG signature (APOL1, ATG4B, CASP3, ITGA3, P4HB, PRKCD, ULK2, and WDR45) exhibited a significant association between mRNA expression levels and overall survival of bladder cancer patients (Figure S1). The gene discussed is CASP3; the disease is urinary bladder cancer.