In the current study, cell lines and human tissue samples collected from 72 patients were utilized to investigate the expression of TMTC4, as depicted in Figure 1A. We initiated our study by evaluating the expression of tmtc3 and tmtc4 on the level of mRNA in a panel of cells including PCa, BPH1 and normal prostatic epithelial PrEC and immortal normal RWPE1 cells. The gene discussed is TMTC3; the disease is posterior cortical atrophy.