We utilized our fibrin-based 3D SMC culture platform to test our hypothesis and demonstrated that administering ASC-derived EVs to SMCs increases the deposition of collagen and elastin, thus highlighting that EVs can be employed as a cell-free therapeutic tool to assist in developing novel treatments aimed at arresting aneurysm growth and fabricating vascular bypass graft material. The gene discussed is ELN; the disease is aneurysm.