ZEB1 and lung cancer: In addition, zinc finger E-box-binding homeobox 1 (ZEB1) acts as an oncogene in invasive and metastatic lung cancer cells, in which the ZEB1-induced epithelial–mesenchymal transition promotes the loss of epithelial cell polarity and adhesion; induces cytoskeleton remodeling; and drives growth, migration, invasion, and metastasis [81,82].