Data analysis of BRAF status in patients enrolled in phase III Keynote 054 trial (adjuvant pembrolizumab versus placebo) revealed a different disease outcome in the placebo group with shorter 3-year RFS for BRAF-mutated versus BRAF wild-type melanomas, whilst no differences were found in the pembrolizumab-treated arm [50]. The gene discussed is BRAF; the disease is melanoma.