In atypical immune response, for example upon infection, DCs activated in theinfected tissue up-take and process pathogen-derived antigens, up-regulateco-stimulatory molecules (e.g., CD80 and CD86, two B7 family members) and thechemokine receptor CCR7, and migrate as “maturing” APCs to draining lymphnodes (LNs) via lymphatic vessels, attracted by CCL19/21, two LN chemokinesrecognized by CCR7 [62]. Here, CD80 is linked to infection.