Identified proteins belong to vital signaling pathways like apoptosis signaling pathway, histamine H1 receptor-mediated signaling pathway, angiogenesis, Alzheimer disease-amyloid secretase pathway, Integrin signaling pathway, alpha-adrenergic receptor signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway, endothelin signaling pathway, EGF receptor signaling pathway, gonadotropin-releasing hormone receptor pathway, thyrotropin-releasing hormone receptor signaling pathway, oxytocin receptor-mediated signaling pathway and blood coagulation shown in Figure 7. Here, TRHR is linked to early-onset autosomal dominant Alzheimer disease.