These two processes are initially triggered by a diffuse endothelial dysfunction induced by SARS-Cov-2 through angiotensin-converting enzyme (ACE-2) receptors and the Transmembrane protease serine 2 (TMPRSS2) that are currently recognized as specific sites by which the virus enters into the vascular system. The gene discussed is TMPRSS2; the disease is endothelial dysfunction.