The cfMeDIP-seq approach has been used by Nassiri et al. to detect CNS tumor plasma methylomes that allow for many brain tumor types to be distinguished with high accuracy including IDH mutant gliomas, IDH wildtype gliomas, meningiomas, hemangiopericytomas, and low grade glioneuronal tumors [68]. The gene discussed is IDH1; the disease is mixed neuronal-glial tumor.