Importantly, in relation to cholesterol and lipoprotein metabolism, apolipoprotein E (APOE) [41], hepatic lipase (LIPC) [44], ATP-binding cassette subfamily A member 1 (ABCA1) [42], and cholesterol ester transfer protein (CETP) [41,45] have been implicated in AMD susceptibility. Here, APOE is linked to age-related macular degeneration.