b-AP15 was also shown to reduce the viability and proliferation of multiple myeloma cells, which mainly correlates with the reduced levels of cell division cycle 25C (CDC25C), cyclin-dependent kinases 1 (CDK1), cyclin B1 and subsequent caspase-mediated apoptosis and activation of unfolded protein response (UPR) [106]. The gene discussed is CDK1; the disease is plasma cell myeloma.