BRAF and neoplasm: BRAF V600E identifies a subgroup of mCRCs with specific clinical (elder age, female gender, right-sided primary tumor location, pattern of metastasization to lymph nodes and peritoneum), pathological (mucinous histology and poor differentiation) and molecular features (CpG island methylator phenotype and high microsatellite instability/mismatch repair deficiency) [2,4,5,6,7,8].