BRAF and neoplasm: In the univariate analysis, besides BRAF non-V600 mutation (HR 0.41; 95%CI 0.18–0.93; p = 0.05), the following baseline characteristics were associated with increased OS: age < 65 years (HR 03.5; 95%CI 0.16–0.74; p = 0.0045), ECOG PS < 1 (HR 0.31; 95%CI 0.13–0.7; p = 0.0007), single site of metastatic spread (HR 0.29; 95%CI 0.14–0.61; p = 0.0029), absence of lung metastases (HR 0.45; 95%CI 0.19–1.03; p = 0.02) and G2 tumor grading (HR 0.26; 95%CI 0.12–0.54; p = 0.0004) (Table 3).