↑ levels of total, endothelial, platelet, and leukocyte EVs between APS pts. and HBDs, between APS pts. and asympt. aPL+ and between asympt. aPL + pts. and HBDs.↑ levels of total EVs in APS triple positivity vs. single positivity.↑ levels of endothelial EVs in asympt. aPL+ triple positivity vs. single positivity. Here, FASLG is linked to autoimmune polyendocrinopathy.