↑ levels of PS+, endoglin+, and endothelial EVs in first and second trimester obstetric APS pts. vs. pregnant HBDs.↑ levels of PS+, endoglin+, TF+, endothelial, and platelet EVs in third trimester obstetric APS pts. vs. pregnant HBDs.↑ levels of endoglin+, TF+, and platelet EVs in high risk (triple aPL positive) pts. compared to low risk (single aPL positive) pts. This evidence concerns the gene ENG and autoimmune polyendocrinopathy.