In one study of non-pregnant obstetric APS patients, increased levels of total EVs were observed compared to healthy non-pregnant women [86]; however, in another study, Breen et al. did not detect increases in specific EVs populations, endothelial (CD51+ or CD105+) and platelet (CD41+ or CD61+), between the two groups [69]. This evidence concerns the gene ITGB3 and autoimmune polyendocrinopathy.