Despite employing the same dosage (25 mg), Litvack et al. always reported a hypofluorescence of PAs as compared to normal pituitary gland tissue, irrespective of their histology, whereas Sandow et al., reported both 100% of hyperfluorescence of ACTH-secreting adenomas (6 out of 6) and a hypofluorescence in GH-secreting adenomas for 9 cases out of 13. This evidence concerns the gene POMC and adenoma.