Here, we focused on TGF-β and E2 found in high concentrations within the tumor [44,55]; both play an essential role in the progression of GBM [42,43,44,45,46,61,62,63], and signaling intersects to be inhibited in other cell types [41,42,43,64,65,66,67]. This evidence concerns the gene TGFB1 and neoplasm.