Of these, seven were excluded because they did not report the outcome of LSCC separately from other locations of HNSCC [12,15,16,17,18,19,20], eight because no HRs were available [21,22,23,24,25,26,27,28,29], one study because they reported outcome in terms of local control [30], one study that evaluated Il-12R expression on tumor cells [31], and one study that evaluated lymphocytes in peripheral blood [32]. This evidence concerns the gene IL12RB1 and neoplasm.