CD8A and neoplasm: Again, in this case the evaluation of CD8+ TIL infiltration was variable: four studies considered only tumor-infiltrating CD8+ cells (CD8+ T cells counts/mm2 of tumor area) and dichotomized the results by the median [9,35,38,39]; one study analyzed tumoral- (CD8+ T cells counts/mm2 of tumor area) and stromal (CD8+ T cells counts/mm2 of stromal area)-infiltrating CD8+ cells dichotomized by the median [37]; and in another one an Immunoscore was used [41], following the methodology described by Galon et al. [8], considering high infiltration a score ≥ 2.