Although it is interesting to note that the depletion of NK cells (or γδ T cells or Gr-1+ monocytes/macrophages/dendritic cells) cells did not prevent tumour regression in our model (Figure 1D), it is possible that IFN-γ had already been released by these cells into the tumour microenvironment prior to their depletion on day 9. This evidence concerns the gene IFNG and neoplasm.