In animals, in two mouse models of type 1 diabetes mellitus, the adipocyte markers, Peroxisome proliferator-activated receptor γ2 (PPARγ2), adipocyte Protein 2 (aP2) and Resistin (RETN) were upregulated in tibia, while Ocn mRNA and osteocalcin serum level decreased [32,33]. The gene discussed is RETN; the disease is type 1 diabetes mellitus.