In addition, Yu et al. conditionally deleted PGC1α in SSCs using Prx1-Cre (Prx1;Pgc1αf/f) and evaluated whether this deletion influenced osteoporotic bone loss and MAT accumulation in mice after ovariectomy, which mimics post-menopausal osteoporosis [13]. The gene discussed is PPARGC1A; the disease is osteoporosis.