AKT1 and lip and oral cavity carcinoma: In gastric cancer cells, 6-gingerol increases sensitivity to radiotherapy through inducing cell cycle arrest and apoptosis [45] and enhancing sensitivity to cisplatin by regulating the PI3K/AKT/mTOR pathway [46,47]; anticancer activity of 6-gingerol has also been demonstrated in human cervical and oral cancer cells via mediation of cell cycle arrest and apoptosis [48].