Despite some slight differences in Aβ deposition in various transgenic mouse models (including AD, amyloid oligomers, and tauopathy model), findings suggested that rifampicin shows marked inhibitory effects on apoptotic pathways, microglial activation, hyperphosphorylation of tau, and accumulation of tau and Aβ oligomers—all these effects being positively linked with neurocognitive outcomes [89]. This evidence concerns the gene MAPT and Alzheimer disease.