PRF1 and ovarian carcinoma: In an analysis of TCGA RNA-sequencing data, the expression of the APOBEC3 family members correlated with T-cell markers in various types of solid cancers and APOBEC3G exhibited a strong correlation with activated cytotoxic T-cell markers, such as granzyme B (GZMB) and perforin (PFR1) in high-grade ovarian cancer (r = 0.6591, p < 0.0001 and r = 0.6422, p < 0.0001, respectively) [22].