TLR2 and periodontal disorder: Previous studies have shown that LPS from Porphyromonas gingivalis prevented apoptosis of HL60-derived neutrophils and the signaling of P. gingivalis through toll-like receptor 2 (TLR2) and may account for the inhibitory effect of P. gingivalis LPS on apoptosis, thus, provided a mechanism for the development of destructive periodontal disease [38,39].