STK11 and cystadenocarcinoma: In this study, we first immunohistochemically characterized the specific LKB1 deletion in the pancreas of the mouse and demonstrated that this results in the development of cystadenocarcinoma, and we reported, for the first time, that the activation of the Wnt signaling pathway and increased nuclear β-catenin activity are the crucial signaling events required for the growth and maintenance of murine MCN in Pdx-1CreLKB1L/L mice.