STK11 and pachyonychia congenita: In summary, our results provide important evidence revealing the association between LKB1 and the Wnt/β-catenin pathway in PC, and we have demonstrated the essential roles of the upregulation of Wnt/β-catenin signaling driven by LKB1 inactivation in promoting MCN formation in vivo and increasing PC cell growth, migration, and invasion in vitro.