STK11 and neoplasm: To understand LKB1-mediated tumor suppression in pancreatic tumorigenesis, we first utilized the pancreatic progenitor-specific Pdx-1 gene promoter-driven Cre recombinase strain to cross with conditional LKB1 loxp/loxp knockout mice, in order to investigate the developmental functions of LKB1 in pancreatic organogenesis and to examine whether pancreas-specific LKB1 deletion triggers pancreatic carcinogenesis in vivo [33,34].