In contrast to DepMap data, which analyzed individual gene knockdowns, the siREN screen knocked down all genes of genetic ‘nodes’ simultaneously; thus the WT RAS node knocked down both HRAS and NRAS. In both colorectal cancer and pancreatic cancer cells, simultaneous knockdown of WT HRAS + NRAS limited survival to a similar extent as knockdown of mutated KRAS did (Figure 2C). This evidence concerns the gene HRAS and familial pancreatic carcinoma.