This observation reflects previous observations that KRAS-mutated lung adenocarcinoma cells are “KRAS-independent” in 2D culture [55,56,57,58,59], but still require KRAS for anchorage-independent growth [60,61,62,63], and some KRASG12C-mutated NSCLC cell lines respond to KRASG12C inhibitors in 3D culture and in vivo but not in 2D adherent culture [16]. This evidence concerns the gene KRAS and lung adenocarcinoma.